Early treatment is usually administered per day. Then the dose over several days to two weeks, the dose is gradually increased until a therapeutic effect. The maintenance dose is generally 2 tablets. The maximum dose – 3 tablets per day. To reduce the side effects from the gastrointestinal tract daily dose should be divided into two steps, taken during or after a meal. Tablets are taken as a whole, without chewing and drinking water.
Due to the increased risk trenbolone acetate of lactic acidosis, formin dose should be reduced in severe metabolic disturbances and the appointment of elderly patients.
First formin treatment can be given as monotherapy or in combination with a sulfonylurea when careful assessment of contraindications.
Interaction with other lekarstvennymisredstvami.
During treatment formin avoid intake of alcohol, as it further reduces the blood glucose level, and causes an increase in lactic acid concentration.
Application formin in combination with other drugs (insulin, sulfonylureas and acarbose) can enhance the hypoglycemic effect. This action can be strengthened and certain other drugs, such as non-steroidal anti-inflammatory drugs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide and its derivatives, β-blockers. Action formin decreases when the simultaneous use of some drugs: glucocorticoids, a combination of estrogen and progestin, the adrenaline and other sympathomimetics, glucagon, thyroid hormones, thiazide and “loop” diuretics, diazoxide, phenothiazines, nicotinic acid derivatives.
EliminatsiyuFormina cimetidine slows down, resulting in increased risk of developing lactic acidosis.
Formin may weaken the effect of anticoagulants (coumarin derivatives).
Formin generally well tolerated, despite the fact that early treatment at 5-20% of patients having disorders of the digestive tract such as nausea, vomiting, abdominal pain, diarrhea, lack of appetite, appearance metallic taste in the mouth. These side effects do not require discontinuation of therapy. In the application of small doses in the beginning of the treatment and the gradual increase, while taking the drug during or after eating frequency of side effects is reduced. If the violations are observed over a long period of time, formin treatment should be discontinued.
Called formin lactic acidosis occurs in extremely rare cases, however, a serious side effect with possible fatal outcome. Besides overdose, lactic acidosis can occur due to violations of the kidneys and liver, alcohol consumption, cardiac decompensation, severe infectious diseases and catabolic states, as well as interaction with other drugs.
In very rare cases, there are allergic skin reactions.
The treatment formin noted isolated cases of malabsorption of vitamin B12 and folic acid.
In the combination therapy trenbolone acetate formin and a sulfonylurea drug to patients is not recommended driving vehicles and operating machinery due to the possible occurrence of hypoglycemia.
In case of overdose formin may develop lactic acidosis fatal. The reason for the development of lactic acidosis may also be the formin accumulation due to impaired renal function. Early symptoms of lactic acidosis include nausea, vomiting, diarrhea, fever, abdominal pain, muscle pain, further marked shortness of breath, dizziness, impaired trenbolone acetate consciousness and coma development. If signs of lactic acidosis, formin treatment must be stopped immediately, and the patient hospitalized immediately, determine the concentration of lactate and formin, confirm the diagnosis. The most effective measure for removal from the body, and lactate is formin hemodialysis. Spend as symptomatic treatment. In combination therapy with sulfonylurea formin may develop hypoglycaemia.