In an application with sulfonylureas, acarbose, insulin, non-steroidal anti-inflammatory drugs, monoamine oxidase inhibitors, oxytetracycline, angiotensin converting enzyme inhibitors, derivatives of clofibrate, cyclophosphamide, (3-blockers may increase the hypoglycemic effect of metformin.
While the use of corticosteroids, oral contraceptives, epinephrine, sympathomimetics, glucagon, thyroid hormones, thiazide and “loop” diuretics, phenothiazine derivatives, derivatives of nicotinic acid may reduce the hypoglycemic action of metformin.
cimetidine slows the elimination of metformin, thus increasing the risk of lactic acidosis.
metformin may weaken the effect of anticoagulants ( coumarin derivatives). Together with the admission of alcohol may develop lactic acidosis. Nifedipine increases absorption, maximum tren acetate concentration, slows excretion of metformin.
Cationic drugs (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, vancomycin), secreted in the tubules, compete for tubular transport system and long-term therapy can increase the maximum concentration of the drug by 60%.
During treatment necessary to monitor renal function. At least tren acetate 2 times a year, as well as the appearance of myalgia should determine the content of lactate in plasma.
Perhaps Formetin use of the drug in combination with a sulfonylurea. In this case, you need particularly careful monitoring of blood glucose levels.
Effects on ability to drive vehicles and operate machinery:
When used as monotherapy Formetin not affect the ability to drive vehicles and operate machinery.
When combined Formetina with other hypoglycemic agents (sulfonylureas, insulin, etc.) may develop hypoglycemic conditions in which deteriorates the ability to manage vehicles and tren acetate occupation of other potentially hazardous activities that require increased attention and rapid psychomotor reactions.