Inside, regardless of meals. Monotherapy : the recommended once daily. Combination therapy : The recommended dose trenbolone acetate cycle once daily in combination with metformin. The starting combination therapy with metformin : the recommended dose Forsiga preparation ™ is 10 mg once a day dose of metformin – 500 mg once a day. In case of inadequate glycemic control, the dose of metformin should be increased.
Use in specific patient populations Patients with impaired liver function in violation of the liver mild or moderate severity is not necessary to adjust the dose of the drug. Patients with impaired liver function severe recommended initial dose of 5 mg. With good endurance dose can be increased to 10 mg (see. Forums “Pharmacokinetics” and “Cautions”). Patients with impaired renal functionEfficiency dapagliflozin is dependent on renal function in patients with moderate degrees of renal dysfunction severity of treatment efficacy is reduced, and in patients with severe impairment – probably absent. The drug Forsiga ™ is contraindicated in patients with renal insufficiency, moderate and severe or with end-stage renal disease . When violations of mild renal function there is no need to adjust the dose. Children Safety and efficacy of dapagliflozin in patients under 18 years have not been studied (see. section “Contraindications”). elderly patients the elderly is not necessary to adjust the dose of the drug. However, when choosing the dose should be considered that these patients are more likely to impaired renal function and reduce the risk of blood volume . Since clinical experience with the drug in patients 75 years and older is limited, start dapagliflozin therapy is contraindicated in this age group.
Side effects Summary of the safety profile in trenbolone acetate cycle pre-planned analysis of pooled data included the results of 12 placebo-controlled trials in which 1,193 patients received dapagliflozin 10 mg and 1393 patients received placebo. The overall incidence of adverse events (short-term therapy) in patients treated with dapagliflozin 10 mg, was similar to that in the placebo group. The number of adverse events that led to the cancellation of treatment, was small and balanced between treatment groups. The most common adverse events with withdrawal therapy dapagliflozin 10 mg, were increase in blood creatinine concentration .
The table shows the data of the drug up to 24 weeks (short-term therapy regardless of the additional hypoglycemic agents. g See the appropriate section below for more information. c Vulvovaginitis, balanitis and similar genital infections include, for example, the following predefined preferred terms: vulvovaginal mycotic . infection, vaginal infection, balanitis, fungal infection of the genital organs of vulvovaginal candidiasis, vulvovaginitis, candida balanitis, genital candidiasis, genital infections, genital infections in men, an infection of the penis vulva, bacterial vaginosis, an abscess of the vulva dpolyuria includes preferred terms: pollakiuria ., polyuria and increased diuresis e Reduction of includes, for example, the following predefined preferred terms:. dehydration, hypovolemia, hypotension f change the following parameters as a percentage of baseline values in the group of dapagliflozin 10 mg, and placebo, respectively, were as follows: total cholesterol 1.4% compared to 0.4%; trenbolone acetate cycle cholesterol by 5.5% compared to 3.8%; LDL cholesterol of 2.7% compared to -1.9 ps%; triglycerides -5.4% compared with% -0.7. g