It should be used with caution in patients with diseases of the gastrointestinal tract, such as dysphagia, gastritis, duodenitis, peptic ulcer in the acute stage, active trenbolone acetate for sale gastrointestinal bleeding or surgery in the upper gastrointestinal tract in history, hypovitaminosis D.
Application of pregnancy and during breastfeeding
The is contraindicated in pregnancy and during breastfeeding.
Not for use alendronate data in pregnant women, but animal studies have been identified violation of the formation of bone tissue of the fetus in the application of high doses of alendronate and dysfunction of labor, associated with hypocalcemia. Do not use the drug during pregnancy.
It is not known whether alendronate passes into breast milk, therefore the use of the drug during breast-feeding is contraindicated.
Dosing and Administration
Inside. The drug should be used in providing the daily requirements of calcium and vitamin D. The optimal duration of use of the drug has not been established. The need for continued therapy bisphosphonates should be evaluated on a regular basis, particularly after 5 or more years of use. In order to ensure proper absorption tablets should be taken in the morning fasting for at least 30 minutes before the first meal, drink or other drugs, with a glass of ordinary water (at least 200 ml). Other drinks (including mineral water) can reduce the absorption of the drug. Should only be taken after full awakening and getting up; 2) tablets swallowed whole (do not chew, dissolve, or dissolve them in the mouth due to the possible formation of ulcers in the mouth and throat, and 3) should not take a horizontal position before the first meal (the first meal – no earlier than 30 minutes after administration of the drug); 4) Do not take the medication at bedtime or before the morning rise from the bed. The recommended dose is 70 mg (1 tablet) once a week. For elderly patients and patients with hepatic impairment, moderate renal impairment (creatinine clearance greater than 35 mL / min) dose adjustment is required. patients with severe renal impairment, the drug is not recommended as there is no experience of use in this population.
In a one-year study conducted trenbolone acetate for sale in women able to postmenopausal osteoporosis, the general security profiles receiving alendronate once a week at a dose of 70 mg (n = 519) and 10 mg / day (n = 370) were the same.
The two three-year studies of virtually identical design, conducted among post-menopausal women (alendronate 10 mg: n = 196; placebo: n = 397), the overall alendronate safety profiles of 10 mg / day and placebo were similar.
In clinical practice (including data from clinical trials and post-marketing use of data) reported the following adverse effects, which are classified according to their rate of development (the trenbolone acetate for sale classification): very common), frequency unknown – the available data to set the frequency of occurrence is not possible. on the part of the immune system rare: hypersensitivity reactions (including flushing of the skin, urticaria, angioedema). on the part of metabolism and nutrition rare:symptomatic hypocalcemia (often associated with conditions predisposing to it) ; very rare: asymptomatic transient hypophosphatemia. From the nervous system common: dizziness, headache uncommon:dysgeusia, the frequency is not known: irritability. From a sight organ infrequently: scleritis, uveitis (inflammation of the choroid) and episcleritis (inflammation of the connective tissue between the sclera and conjunctiva).